Abstract
Introduction: Tobacco is the major risk factor for obstructive pulmonary disease (COPD) and lung cancer. Therefore stopping smoking is the most effective way of halting or slowing the progress of this disease. Medically inoperable patients with early stage lung cancer with central or peripheral lesions could be safely treated by stereotactic radiotherapy (SBRT). This case-control study aims to investigate the role of smoking cessation on functional variations after radiotherapy and the impact on response rate. Methods: Forty-five smokers patients with moderate COPD and affected by non-small cell lung cancer stage T1-3N0M0 were progressively enrolled. They underwent successful smoking cessation program with varenicline or NRT (nicotine replacement therapy), at the time stereotactic body radiotherapy (SBRT) was undertaken.
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Contact: cancerbiology@sciaeonopenaccess.com
Journal of Cancer Biology and Clinical Oncology 