Acquired pure red cell aplasia is a rare disorder in which the bone marrow makes almost no red blood cells. It may be caused by infection or by certain drugs. Patients with this disorder may also have a thymoma (a tumor of the thymus) or an autoimmune condition such as lupus erythematosus or rheumatoid arthritis. Affected individuals may experience fatigue, lethargy, and/or abnormal paleness of the skin (pallor). Acquired Pure Red Cell Aplasia may occur for unknown reasons (idiopathic) or as a primary autoimmune disorder. It is also believed that Acquired Pure Red Cell Aplasia may occur secondary to a tumor of the thymus gland (thyoma), viral infections, or certain drugs. Acquired Pure Red Cell Aplasia is characterized by a decrease in the number of red blood cells produced in the bone marrow. Individuals with this disorder are deficient in the number of precursors of red blood cells (erythroblasts). Levels of the hormone erythropoietin that stimulates the bone marrow to produce red blood cells are usually elevated. Affected individuals may experience fatigue, lethargy, and/or abnormal paleness of the skin (pallor).
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Journal of Cancer Biology and Clinical Oncology 