Bone cancer is very rare in adults. It starts in the cells that make up the bone. Cancer starts when cells begin to grow out of control. Cells in nearly any part of the body can become cancer, and can spread to other parts of the body. Bone is the supporting framework of your body. Most bones are hollow. The hard outer layer of bones is made of compact (cortical) bone, which covers the lighter spongy (trabecular) bone inside. The outside of the bone is covered with fibrous tissue called periosteum. Hollow bones have a space called the medullary cavity which contains the soft, spongy tissue called bone marrow (discussed below). The tissue lining the medullary cavity is called endosteum.
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Journal of Cancer Biology and Clinical Oncology 