Metastasis is the spread of cancer cells to new areas of the body, often by way of the lymph system or bloodstream. A metastatic cancer, or metastatic tumor, is one that has spread from the primary site of origin, or where it started, into different areas of the body. Tumors formed from cells that have spread are called secondary tumors. The cancer may have spread to areas near the primary site, called regional metastasis, or to parts of the body that are farther away, called distant metastasis.
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Journal of Cancer Biology and Clinical Oncology 