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abiraterone acetate

A drug used with prednisone to treat prostate cancer that has spread to other parts of the body. It is used in patients whose cancer is castration resistant (has not responded to treatments that lower testosterone levels) or whose cancer is high risk and castration sensitive (has responded to treatments that lower testosterone levels). It is also being studied in the treatment of other types of cancer. Abiraterone acetate lowers the amount of androgens (male hormones), such as testosterone, made by the body. This may stop the growth of cancer cells that need androgens to grow. Abiraterone acetate is a type of antiandrogen. Also called Zytiga.

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ABI-007

A drug used to treat breast cancer that has come back or spread to other parts of the body. It is also used with carboplatin to treat advanced non-small cell lung cancer in patients who are not able to have surgery or radiation therapy. It is also used with gemcitabine hydrochloride to treat pancreatic cancer that has spread to other parts of the body. It is being studied in the treatment of other types of cancer. ABI-007 is a form of the anticancer drug paclitaxel and may cause fewer side effects than paclitaxel. It stops cancer cells from growing and dividing, and may kill them. It is a type of mitotic inhibitor and a type of antimicrotubule agent. Also called Abraxane, nanoparticle paclitaxel, paclitaxel albumin-stabilized nanoparticle formulation, and protein-bound paclitaxel.

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ABCA1 pathway

Describes a group of proteins in a cell that work together to help remove extra cholesterol and certain fats from tissue in the body. Changes in the ABCA1 pathway may lead to diseases of the heart and blood vessels. Drugs or substances that affect this pathway are being studied in the prevention and treatment of some diseases.

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Abarelix

A drug used to reduce the amount of testosterone made in patients with advanced symptomatic prostate cancer for which no other treatment options are available. It belongs to the family of drugs called gonadotropin-releasing hormone (GnRH) antagonists. Also called Plenaxis.

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Parenchyma

Parenchyma is the bulk of a substance. In animals, a parenchyma comprises the functional parts of an organ and in plants parenchyma is the ground tissue of nonwoody structures. The parenchyma is the functional parts of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, namely, the connective tissues. The brain parenchyma refers to the functional tissue in the brain that is made up of the two types of brain cell, neurons and glial cells. Damage or trauma to the brain parenchyma often results in a loss of cognitive ability or even death. Lung parenchyma is the substance of the lung outside of the circulation system that is involved with gas exchange and includes the alveoli and respiratory bronchioles. In cancer, the parenchyma refers to “The portion of a tissue that lies outside the circulatory system and is often responsible for carrying out the specialized functions of the tissue”.

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Epithelium

Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. Epithelial tissues line the outer surfaces of organs and blood vessels throughout the body, as well as the inner surfaces of cavities in many internal organs. An example is the epidermis, the outermost layer of the skin.

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Bone tumor

A bone tumor is a neoplastic growth of tissue in bone. Abnormal growths found in the bone can be either benign (noncancerous) or malignant (cancerous). Average five-year survival in the United States after being diagnosed with bone and joint cancer is 67%.

Bone tumors may be classified as “primary tumors”, which originate in bone or from bone-derived cells and tissues, and “secondary tumors” which originate in other sites and spread (metastasize) to the skeleton. Carcinomas of the prostate, breasts, lungs, thyroid, and kidneys are the carcinomas that most commonly metastasize to bone. Secondary malignant bone tumors are estimated to be 50 to 100 times as common as primary bone cancers.

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Carcinoma

Carcinoma is a category of types of cancer that develop from epithelial cells. Specifically, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that arises from cells originating in the endodermal, mesodermal or ectodermal germ layer during embryogenesis. Carcinomas occur when the DNA of a cell is damaged or altered and the cell begins to grow uncontrollably and become malignant.

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Cancer prevention

Cancer prevention is the practice of taking active measures to decrease the incidence of cancer and mortality.The practice of prevention is dependent upon both individual efforts to improve lifestyle and seek preventative screening, and socioeconomic or public policy related to cancer prevention. Globalized cancer prevention is regarded as a critical objective due to its applicability to large populations, reducing long term effects of cancer by promoting proactive health practices and behaviors, and its perceived cost-effectiveness and viability for all socioeconomic classes.

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Invasion (cancer)

For cancer, invasionis the direct extension and penetration by cancer cells into neighboring tissues. It is generally distinguished from metastasis, which is the spread of cancer cells through the circulatory system or the lymphatic system to more distant locations. Yet, lymphovascular invasion is generally the first step of metastasis.

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