Nail clubbing, also known as digital clubbing, is a deformity of the finger or toe nails associated with a number of diseases, mostly of the heart and lungs. When it occurs together with joint effusions, joint pains, and abnormal skin and bone growth it is known as hypertrophic osteoarthropathy.
Clubbing is associated with lung cancer, lung infections, interstitial lung disease, cystic fibrosis, and cardiovascular disease.Clubbing can run in families,and it may also occur unassociated with any other medical condition.
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Journal of Cancer Biology and Clinical Oncology 